Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I’m a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients.
In this podcast, Dr. Warrick Bishop discusses the movement of lipids and lipoprotein particles in the body, emphasizing their role in delivering energy sources. He explains that dietary fats absorbed in the gut form chylomicrons, which enter the bloodstream and release triglycerides to tissues via the enzyme lipoprotein lipase. As triglycerides are removed, these particles become denser and transform into intermediate and low-density lipoproteins (IDL and LDL), which are remnants of energy delivery. The liver produces very low-density lipoproteins (VLDL) to perform a similar function.
Dr. Bishop clarifies that while the liver does not produce LDL cholesterol, it can uptake it from the bloodstream, especially when cholesterol production is inhibited by medications like statins. He highlights the distinction between measured LDL cholesterol in the bloodstream and cholesterol available in cells, noting that cells can both absorb LDL and synthesize cholesterol. The discussion emphasizes the importance of understanding these processes in the context of energy delivery and cellular repair. Additionally, Dr. Bishop briefly addresses a listener's question about AV ablation, explaining its significance in managing atrial fibrillation and heart rate control. He concludes by encouraging listeners to reach out with further questions.
Takeaways:
- Lipoprotein particles primarily serve to deliver energy sources throughout the body, with the gut absorbing fats and forming chylomicrons that enter the bloodstream.
- Lipoprotein lipase is an enzyme that acts on chylomicrons, extracting triglycerides for use by various tissues, which leads to the formation of denser lipoprotein remnants.
- Low-density lipoprotein (LDL) cholesterol is a remnant of the lipid processing that can contribute to coronary artery disease when present in excess within blood vessels.
- The liver produces very low-density lipoprotein (VLDL), which functions similarly to chylomicrons by delivering triglycerides to tissues before leaving behind remnants.
- Cholesterol is necessary for various bodily functions, and every tissue has LDL receptors to absorb it for synthesis and repair.
- Statins and similar agents work by blocking the HMG-CoA reductase pathway, reducing cholesterol production in cells, which prompts cells to increase LDL receptor expression to absorb more cholesterol from the bloodstream.
- The cholesterol measured in blood tests reflects the amount of LDL particle cholesterol circulating, not the total cholesterol present in individual cells.
- Cells can either absorb LDL cholesterol from the bloodstream or synthesize cholesterol through their metabolic pathways.
- Understanding the distinction between circulating LDL cholesterol and cellular cholesterol uptake is crucial for comprehending lipid metabolism and its implications for health.
- Atrial fibrillation treatments, such as AV nodal ablation, may be necessary for certain patients, but it is generally preferable to manage the condition without such interventions if possible.
Australia, like the rest of the western world, has a heart problem.
Over 9 million people around the world die from heart disease every year.
Every 10 minutes, someone in Australia suffers a heart attack. And 21 lives are lost daily because of it.
The devastating fact in all of this is…
Almost every one of those cases could have been prevented.
This podcast is for anyone who wants to improve their health literacy and gain information to help them make the best decisions about their risk of heart attack, their cholesterol, blood pressure, risk of diabetes, weight loss and general health. Join me on my personal mission journey to prevent Heart Attack on a global scale. If you like this podcast, I would be honoured by a 5-star review and appreciate if you let your friends and family know about this podcast; you may even save the life of someone you love!
Are You at Risk of a Sudden Heart Attack? How Healthy is Your Heart? Really?
Heart disease is the #1 killer in the Western World. In Australia, someone dies every 28 minutes from heart disease. That’s 51 people a day. In the US, someone has a heart attack every 40 SECONDS! Fortunately, many heart attacks are preventable. However, regular exercise and eating healthy are no guarantee you won’t succumb to this silent killer.
- 94% of Australians have at least One Risk Factor for heart disease.
- 59% of Australians have been Touched by heart disease.
- Yet only 3% of Australians have had a Full Heart-Health Assessment in the past 12 months.
Do the free heart check today at www.virtualheartcheck.com.au
Join the Healthy Heart Network and become part of our growing community!
Do You Want to Improve Your Heart’s Health and Reduce Your Risk of Suffering a Heart Attack? Join The Healthy Heart Network For Only $5 Lifetime Access (Valued at over $55)!
The Healthy Heart Network is designed to help members:
- understand the present state of their heart’s health
- recognise their current level of risk of suffering a heart attack
- Learn the positive steps they can take to improve their situation
Visit https://healthyheartnetwork.com/ and click on the JOIN THE FAMILY BUTTON
